Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation.

ABSTRACT:

Background

Iron sulfide nanomaterials have been successfully employed as therapeutic agents for bacterial infection therapy and catalytic-ferroptosis synergistic tumor therapy due to their unique structures, physiochemical properties, and biocompatibility. However, biomedical research and understanding of the biological functions of iron sulfides are insufficient, and how iron sulfide nanomaterials affect reactive oxygen species (ROS) in diseases remains unknown. Acute kidney injury (AKI) is associated with high levels of ROS, and therefore nanomedicine-mediated antioxidant therapy has emerged as a novel strategy for its alleviation.

Results

Here, mackinawite nanozymes were synthesized from glutathione (GSH) and iron ions (Fe³⁺) (denoted as GFeSNs) using a hydroth

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10439570 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature