Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.

ABSTRACT:

Introduction

Migraine, a prevalent headache disorder with unclear mechanisms and limited treatments, may be influenced by dyslipidemia and genetic factors. Statins and emerging lipid-modifying agents show potential but lack evidence for migraine management. Mendelian Randomization analysis offers insights into causal relationships and therapeutic targets. This study aims to explore genetically predicted lipid traits, drug targets, and their association with migraine risk.

Method

We conducted Mendelian randomization (MR) analyses utilizing genetic variants associated with lipid traits and variants in genes encoding the protein targets of various classes of lipid-lowering drugs. The specific drug classes investigated included HMGCR, PCSK9, NPC1L1, ABCG5/ABCG8, LDLR, LPL, ANGPT

SUBMITTER: Bi Y 

PROVIDER: S-EPMC10439594 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature