Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation.

ABSTRACT: A number types of extracellular DNA (eg, cell-free, cfDNA) circulate in human blood, including mitochondrial, transcriptome, and regulatory DNA, usually at low concentrations. Larger amounts of cfDNA appear in any inflammatory condition, including organ damage due to a variety of reasons. The role of cfDNA in solid organ transplantation is discussed in this review as a valuable additional tool in the standard of care of transplant patients. Post-transplant monitoring requires the use of high-quality biomarkers for early detection of graft damage or rejection to be able to apply early therapeutic intervention. CfDNA complements the traditional monitoring strategies, being a risk stratification tool and an important prognostic marker. However, improving the sensitivity and specificity of cfD

SUBMITTER: Raszeja-Wyszomirska J 

PROVIDER: S-EPMC10439677 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature