Hub gene associated with prognosis in bladder cancer is a novel therapeutic target.

ABSTRACT:

Objective

Bladder cancer is a clinical and social conundrum due to its high incidence and recurrence rate. It is urgent to find new targets for the diagnosis and treatment of bladder cancer and improve the prognosis and survival rate of bladder cancer patients. We sought a prognosis-related gene, built related models of evaluated bladder cancer and identified the function of the hub gene in bladder cancer.

Methods

We downloaded the data of bladder cancer patients from the TCGA database, and used differentially expressed genes (DEGs), copy number variation (CNV) and survival analysis to scan the hub genes associated with prognosis in bladder cancer. Then, multi-factor cox regression was used to obtain the bladder cancer prognosis correlation model. Then, we analyzed the relat

SUBMITTER: Fang D 

PROVIDER: S-EPMC10439716 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature