Ontology highlight
ABSTRACT:
SUBMITTER: Hoffnagle AM
PROVIDER: S-EPMC10439731 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Hoffnagle Alexander M AM Tezcan F Akif FA
Journal of the American Chemical Society 20230623 26
We report a new computational protein design method for the construction of oligomeric protein assemblies around metal centers with predefined coordination geometries. We apply this method to design two homotrimeric assemblies, Tet4 and TP1, with tetrahedral and trigonal-pyramidal tris(histidine) metal coordination geometries, respectively, and demonstrate that both assemblies form the targeted metal centers with ≤0.2 Å accuracy. Although Tet4 and TP1 are constructed from the same parent protein ...[more]