Advanced glycation end products impair coronary artery BK channels via AMPK/Akt/FBXO32 signaling pathway.

ABSTRACT: Background: Advanced glycation end products (AGEs) impair vascular physiology in Diabetes mellitus (DM). However, the underlying mechanisms remain unclear. Vascular large conductance calcium-activated potassium (BK) channels play important roles in coronary arterial function.Purpose: Our study aimed to investigate the regulatory role of AGEs in BK channels.Research Design: Using gavage of vehicle (V, normal saline) or aminoguanidine (A) for 8 weeks, normal and diabetic rats were divided into four groups: C+V group, DM+V group, C+A group, and DM+A group.Study Sample: Coronary arteries from different groups of rats and human coronary smooth muscle cells were used in this study.Data Collection and Analysis: Data were presented as mean ± SEM (standard error o

SUBMITTER: Li XY 

PROVIDER: S-EPMC10439763 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature