MALAT1 in Liquid Biopsy: The Diagnostic and Prognostic Promise for Colorectal Cancer and Adenomas?

ABSTRACT:

Introduction

The development of colorectal cancer (CRC) is a multistep process accompanied by the accumulation of mutations that start from specific precancerous lesion - colorectal adenomas (CA). CRC incidence and mortality can be reduced by the early identification of these neoplasm. Colonoscopy is the most widely used screening method for CRC identification. Nowadays, clinical research interest is shifting to the use of liquid biopsy that may help with the early diagnosis of CA and CRC. In our previous study, we identified long non-coding RNA MALAT1 gene amplification associated with the development of CA.

Methods

This study aimed to describe the potential of MALAT1 expression levels in the adenoma tissue of patients used in the previous study by real-time q

SUBMITTER: Cervena K 

PROVIDER: S-EPMC10439781 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature