GINGER: an integrated method for high-accuracy prediction of gene structure in higher eukaryotes at the gene and exon level.

ABSTRACT: The prediction of gene structure within the genome sequence is the starting point of genome analysis, and its accuracy has a significant impact on the quality of subsequent analyses. Gene structure prediction is roughly divided into RNA-Seq-based methods, ab initio-based methods, homology-based methods, and the integration of individual prediction methods. Integrated methods are mainstream in recent genome projects because they improve prediction accuracy by combining or taking the best individual prediction findings; however, adequate prediction accuracy for eukaryotic species has not yet been achieved. Therefore, we developed an integrated tool, GINGER, that solves various issues related to gene structure prediction in higher eukaryotes. By handling artefacts in alignments of RNA and pro

SUBMITTER: Taniguchi T 

PROVIDER: S-EPMC10439787 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature