Escherichia coli high-risk clone ST410 harboring bla_NDM-13 isolated from hospital wastewater in China.

ABSTRACT: A carbapenem-resistant Escherichia coli strain C-SRM-3 was isolated from hospital wastewater effluent in Hangzhou city, China in March 2022. Analysis of the whole genome sequence showed that this bla_NDM-13-positive strain belonged to an internationally recognized high-risk clone ST410 responsible for the dissemination of carbapenem resistance in E. coli. This isolate displayed a multidrug-resistant phenotype and carried a cassette of antibiotic-resistant genes. bla_NDM-13 gene was successfully transferred to the recipient E. coli C600 via conjugation. WGS results revealed that bla_NDM-13 gene was located on an IncI1 type plasmid replicon. The phylogenetic reconstruction showed that wastewater-sourced C-SRM-3 strain was located in a single branch, far removed

SUBMITTER: Ju X 

PROVIDER: S-EPMC10439849 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature