Brain-cognition relationships in late-life depression: a systematic review of structural magnetic resonance imaging studies.

ABSTRACT:

Background

Most patients with late-life depression (LLD) have cognitive impairment, and at least one-third meet diagnostic criteria for mild cognitive impairment (MCI), a prodrome to Alzheimer's dementia (AD) and other neurodegenerative diseases. However, the mechanisms linking LLD and MCI, and brain alterations underlying impaired cognition in LLD and LLD + MCI remain poorly understood.

Methods

To address this knowledge gap, we conducted a systematic review of studies of brain-cognition relationships in LLD or LLD + MCI to identify circuits underlying impaired cognition in LLD or LLD + MCI. We searched MEDLINE, PsycINFO, EMBASE, and Web of Science databases from inception through February 13, 2023. We included studies that assessed cognition in patients with LLD or LLD + MC

SUBMITTER: Marawi T 

PROVIDER: S-EPMC10439902 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature