Time-dependent variations in BK polyomavirus genome from kidney transplant recipients with persistent viremia.

ABSTRACT: BK polyomavirus (BKPyV) is a human DNA virus that resides latent in the host's renal tissue. Reactivation occurs occasionally and in case of kidney transplantation, it can lead to polyomavirus-associated nephropathy (PVAN). Due to the lack of specific antivirals for BKPyV and despite the risk of allograft rejection, reduction of immunosuppression remains the main approach for treating PVAN. Current data suggests that mutations can accumulate over time in the major capsid protein VP1 and can lead to neutralization escape in kidney transplant recipients. Herein, we show that mutations occur throughout the entire BKPyV genome, including in VP1. Changes were identified by per-patient comparison of viral genome sequences obtained in samples from 32 kidney recipients with persistent viremia coll

SUBMITTER: Mineeva-Sangwo O 

PROVIDER: S-EPMC10439958 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature