A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma.

ABSTRACT: Asthma is a chronic disease most commonly associated with allergy and type 2 inflammation. However, the mechanisms that link airway inflammation to the structural changes that define asthma are incompletely understood. Using a human model of allergen-induced asthma exacerbation, we compared the lower airway mucosa in allergic asthmatics and allergic non-asthmatic controls using single-cell RNA sequencing. In response to allergen, the asthmatic airway epithelium was highly dynamic and up-regulated genes involved in matrix degradation, mucus metaplasia, and glycolysis while failing to induce injury-repair and antioxidant pathways observed in controls. IL9-expressing pathogenic T_H2 cells were specific to asthmatic airways and were only observed after allergen challenge. Addi

SUBMITTER: Alladina J 

PROVIDER: S-EPMC10440046 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature