Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach.

ABSTRACT:

Objectives

Sodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a flavonoid with many biological properties found naturally in honey and plants. This study aimed to determine the effects of ZNG on SA-induced rat lung toxicity.

Materials and methods

Thirty-five male Sprague rats were divided into Control, SA, ZNG, SA+ZNG25, and SA+ZNG50 groups (n=7). SA 10 mg/kg and ZNG were administered at two doses (25 and 50 mg/kg) (orally, 14 days). Analysis of oxidative stress, inflammation damage, apoptosis damage, and autophagic damage markers in lung tissue were determined by biochemical and histological methods.

Results

The administration of ZNG reduced oxidative stress by increasing SA-induced decreased antioxidant enzyme activities, increasing Nrf-2, HO-1,

SUBMITTER: Simsek H 

PROVIDER: S-EPMC10440130 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature