Placental growth factor as a sensitive biomarker for vascular cognitive impairment.

ABSTRACT:

Introduction

High-performing biomarkers measuring the vascular contributions to cognitive impairment and dementia are lacking.

Methods

Using a multi-site observational cohort study design, we examined the diagnostic accuracy of plasma placental growth factor (PlGF) within the MarkVCID Consortium (n = 335; CDR 0-1). Subjects underwent clinical evaluation, cognitive testing, MRI, and blood sampling as defined by Consortium protocols.

Results

In the prospective population of 335 subjects (72.2 ± 7.8 years of age, 49.3% female), plasma PlGF (pg/mL) shows an ordinal odds ratio (OR) of 1.16 (1.07-1.25; P = .0003) for increasing Fazekas score and ordinal OR of 1.22 (1.14-1.32; P < .0001) for functional cognitive impairment measured by the Clinical Dementia Rating scale. We a

SUBMITTER: Hinman JD 

PROVIDER: S-EPMC10440207 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature