Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.

ABSTRACT:

Background

Single-cohort studies have identified distinct neurobehavioral profiles that are associated with prenatal and neonatal factors based on the NICU Network Neurobehavioral Scale (NNNS). We examined socioeconomic, medical, and substance use variables as predictors of NNNS profiles in a multi-cohort study of preterm and term-born infants with different perinatal exposures.

Methods

We studied 1112 infants with a neonatal NNNS exam from the Environmental influences on Child Health Outcomes (ECHO) consortium. We used latent profile analysis to characterize infant neurobehavioral profiles and generalized estimating equations to determine predictors of NNNS profiles.

Results

Six distinct neonatal neurobehavioral profiles were identified, including two dysregulated pr

SUBMITTER: Camerota M 

PROVIDER: S-EPMC10440230 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature