Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero.

ABSTRACT:

Background

Preeclampsia, especially before term, increases the risk of child neurodevelopmental adverse outcomes. Biological plausibility, preclinical studies, and pilot clinical trials conducted by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Obstetric-Fetal Pharmacology Research Centers Network support the safety and use of pravastatin to prevent preeclampsia.

Objective

This study aimed to determine the effect of antenatal pravastatin treatment in high-risk pregnant individuals on their child's health, growth, and neurodevelopment.

Study design

This was an ancillary follow-up cohort study of children born to mothers who participated in the Obstetric-Fetal Pharmacology Research Centers Network pilot trials of pravastatin

SUBMITTER: Costantine MM 

PROVIDER: S-EPMC10440254 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature