Semantic item-level metrics relate to future memory decline beyond existing cognitive tests in older adults without dementia.

ABSTRACT: In normal aging, the cognitive domain of semantic memory remains preserved, while the domain of episodic memory declines to some extent. In Alzheimer's disease dementia, both semantic and episodic memory become impaired early in the disease process. Given the need to develop sensitive and accessible cognitive markers for early detection of dementia, we investigated among older adults without dementia whether item-level metrics of semantic fluency related to episodic memory decline above and beyond existing neuropsychological measures and total fluency score. Participants were drawn from the community-based Washington Heights-Inwood Columbia Aging Project cohort (N = 583 English speakers, M_age = 76.3 ± 6.8) followed up to five visits across up to 11 years. We examin

SUBMITTER: Vonk JMJ 

PROVIDER: S-EPMC10440298 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature