A novel prognostic prediction model of cuprotosis-related genes signature in hepatocellular carcinoma.

ABSTRACT: Background: Cuprotosis is a recently discovered copper-dependent cell death mechanism that relies on mitochondrial respiration. However, the role of cuprotosis-related genes (CRGs) in hepatocellular carcinoma (HCC) and their prognostic significances remain unknown. Methods: Based on the recently published CRGs, the LASSO Cox regression analysis was applied to construct a CRGs risk model using the gene expression data from the International Cancer Genome Consortium as a training set, followed by validation with datasets from The Cancer Genome Atlas and the Gene Expression Omnibus (GSE14520). Functional enrichment analysis of the CRGs was performed by single-sample gene set enrichment analysis. Results: Five of the 13 previously publish

SUBMITTER: Shao RN 

PROVIDER: S-EPMC10440422 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature