Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes.

ABSTRACT:

Purpose

To assess age-related biometric changes of the eye in nonhuman primates (NHPs), to and decipher the growth and aging rates and their comparability with humans.

Methods

Ocular anatomic measurements were performed on 341 macaca fascicularis aged 0.5 to 23 years via multimodal approaches including IOLMaster 700. Linear or polynomial regression models were simulated to determine the best fitted age-related function. The metrics were compared with human equivalents in published reports.

Results

Macaques exhibited a postnatal eye growth pattern similar to humans, characterized by continuous eye extension coordinated with dramatic reshaping of the lens but not the cornea. The age-related growth of lens thickness (LT), anterior chamber depth (ACD), and axis length (AL

SUBMITTER: Xue Y 

PROVIDER: S-EPMC10440610 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature