The inter-chamber differences in the contractile function between left and right atrial cardiomyocytes in atrial fibrillation in rats.

ABSTRACT:

Introduction

The left and right atria (LA, RA) work under different mechanical and metabolic environments that may cause an intrinsic inter-chamber diversity in structure and functional properties between atrial cardiomyocytes (CM) in norm and provoke their different responsiveness to pathological conditions. In this study, we assessed a LA vs. RA difference in CM contractility in paroxysmal atrial fibrillation (AF) and underlying mechanisms.

Methods

We investigated the contractile function of single isolated CM from LA and RA using a 7-day acetylcholine (ACh)-CaCl₂ AF model in rats. We compared auxotonic force, sarcomere length dynamics, cytosolic calcium ([Ca²⁺]_i) transients, intracellular ROS and NO production in LA and RA CM, and a

SUBMITTER: Butova X 

PROVIDER: S-EPMC10440706 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature