Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections.

ABSTRACT: Insomnia is often comorbid with depression, but the underlying neuronal circuit mechanism remains elusive. Recently, we reported that GABAergic ventral pallidum (VP) neurons control wakefulness associated with motivation. However, whether and how other subtypes of VP neurons regulate arousal and emotion are largely unknown. Here, we report glutamatergic VP (VP^Vglut2) neurons control wakefulness and depressive-like behaviors. Physiologically, the calcium activity of VP^Vglut2 neurons was increased during both NREM sleep-to-wake transitions and depressive/anxiety-like behaviors in mice. Functionally, activation of VP^Vglut2 neurons was sufficient to increase wakefulness and induce anxiety/depressive-like behaviors, whereas inhibition attenuated both. Dissection

SUBMITTER: Luo YJ 

PROVIDER: S-EPMC10440712 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature