Prostate malignant tumor and benign prostatic hyperplasia microenvironments in black African men: Limited infiltration of CD8+ T lymphocytes, NK-cells, and high frequency of CD73+ stromal cells.

ABSTRACT:

Background

Anti-cancerous immunology has yet to be investigated in the African black population, despite being the dawn of precision medicine.

Aim

Here we investigated the tumor microenvironment of prostate cancer and benign prostatic hyperplasia (BPH) in black Africans.

Methods

Through immunohistochemistry analysis of prostate cancer and BPH patients' biopsies, we investigated the expression and distribution of CD73, CCD8 T-lymphocytes, and natural killer cells. In addition, we looked at tumor-infiltrating features CD8 T-lymphocytes and natural killer cells.

Results

We show for the first time in black Africans a high expression of CD73 in epithelial-stromal cells and virtually no infiltration of CD8 T lymphocytes and natural killer cells in the tumoral area. I

SUBMITTER: Mougola Bissiengou P 

PROVIDER: S-EPMC10440842 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature