Kidney function, albuminuria, and their modification by genetic factors and risk of incident dementia in UK Biobank.

ABSTRACT:

Background

Associations between kidney function and dementia risk are inconclusive. Chronic kidney disease (CKD) severity is determined by levels of both estimated glomerular filtration rate (eGFR) and the urine albumin to creatinine ratio (ACR). However, whether there is a graded increase in dementia risk for worse eGFR in each ACR category is unclear. Also, whether genetic risk for dementia impacts the associations is unknown. The current study aims to investigate the associations between eGFR and albuminuria with dementia risk both individually and jointly, whether the associations vary by different follow-up periods, and whether genetic factors modified the associations.

Methods

In 202,702 participants aged ≥ 60 years from the UK Biobank, Cox proportional-hazards models

SUBMITTER: Yeh TS 

PROVIDER: S-EPMC10440913 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature