The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice.

ABSTRACT: Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and diminished interest. Although many clinical and animal studies have provided significant insights into the pathophysiology of depression, current treatment strategies are not sufficient to manage this disorder. It has been suggested that connexin (Cx)-based hemichannels are candidates for depression intervention by modifying the state of neuroinflammation. In this study, we investigated the antidepressant-like effect of a recently discovered selective Cx hemichannel inhibitor, a small organic molecule called D4. We first showed that D4 reduced hemichannel activity following systemic inflammation after LPS injections. Next, we found that D4 treatment prevented LPS-induced inf

SUBMITTER: Li H 

PROVIDER: S-EPMC10440914 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature