Analysis of mRNA m⁶A modification and mRNA expression profiles in middle ear cholesteatoma.

ABSTRACT: Introduction: Middle ear cholesteatoma is characterized by the hyperproliferation of keratinocytes. In recent decades, N⁶-methyladenosine (m⁶A) modification has been shown to play an essential role in the pathogenesis of many proliferative diseases. However, neither the m⁶A modification profile nor its potential role in the pathogenesis of middle ear cholesteatoma has currently been investigated. Therefore, this study aimed to explore m⁶A modification patterns in middle ear cholesteatoma. Materials and methods: An m⁶A mRNA epitranscriptomic microarray analysis was performed to analyze m⁶A modification patterns in middle ear cholesteatoma tissue (n = 5) and normal post-auricular skin samples (n = 5

SUBMITTER: Xie S 

PROVIDER: S-EPMC10441234 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature