Neural crest cells give rise to non-myogenic mesenchymal tissue in the adult murid ear pinna.

ABSTRACT: Despite being a major target of reconstructive surgery, development of the external ear pinna remains poorly studied. As a craniofacial organ highly accessible to manipulation and highly conserved among mammals, the ear pinna represents a valuable model for the study of appendage development and wound healing in the craniofacial complex. Here we provide a cellular characterization of late gestational and postnatal ear pinna development in Mus musculus and Acomys cahirinus and demonstrate that ear pinna development is largely conserved between these species. Using Wnt1-cre;ROSA ^mT/mG mice we find that connective tissue fibroblasts, elastic cartilage, dermal papilla cells, dermal sheath cells, vasculature, and adipocytes in the adult pinna are derived from cra

SUBMITTER: Allen RS 

PROVIDER: S-EPMC10441307 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature