Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction.

ABSTRACT: Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly accurate molecular biomarker of aging. To address this question, we developed and validated six different epigenetic clocks for rat tissues that are based on DNA methylation values derived from n=613 tissue samples. As indicated by their respective names, the rat pan-tissue clock can be applied to DNA methylation profiles from all rat tissues, while the rat brain-, liver-, and blood clocks apply to the corresponding tissue types. We also developed two epigenetic clocks that apply to both human and rat tissues by adding n=1366 human t

SUBMITTER: Horvath S 

PROVIDER: S-EPMC10441355 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature