Antibody Inhibition of Influenza A Virus Assembly and Release.

ABSTRACT: Antibodies are frontline defenders against influenza virus infection, providing protection through multiple complementary mechanisms. Although a subset of monoclonal antibodies (mAbs) have been shown to restrict replication at the level of virus assembly and release, it remains unclear how potent and pervasive this mechanism of protection is, due in part to the challenge of separating this effect from other aspects of antibody function. To address this question, we developed imaging-based assays to determine how effectively a broad range of mAbs against the IAV surface proteins can specifically restrict viral egress. We find that classically neutralizing antibodies against hemagglutinin are broadly multifunctional, inhibiting virus assembly and release at concentrations one- to twenty-fold

SUBMITTER: Yuanyuan H 

PROVIDER: S-EPMC10441363 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature