Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC10441411 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Wang Lei L Xiao Yufeng Y Luo Yuewan Y Master Rohan P RP Mo Jiao J Kim Myung-Chul MC Liu Yi Y Patel Urvi M UM Li Xiangming X Shaffer Donald D Guertin Kevin R KR Moser Emily E Smalley Keiran S KS Zhou Daohong D Zheng Guangrong G Zhang Weizhou W
bioRxiv : the preprint server for biology 20230813
An effective cancer therapy requires both killing cancer cells and targeting tumor-promoting pathways or cell populations within the tumor microenvironment (TME). We purposely search for molecules that are critical for multiple tumor-promoting cell types and identified nuclear receptor subfamily 4 group A member 1 (NR4A1) as one such molecule. NR4A1 has been shown to promote the aggressiveness of cancer cells and maintain the immune suppressive TME. Using genetic and pharmacological approaches, ...[more]