Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection.

ABSTRACT: People with HIV (PWH) experience an increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors that contribute to or are associated with this vulnerability remain uncertain. In the general population, alterations in the glycomes of circulating IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG glycomes of cross-sectional and longitudinal samples from 1,216 women and men, both living with virally suppressed HIV and those without HIV. Our glycan-based machine learning models indicate that living with chronic HIV significantly accelerates the accumulation of pro-aging-associated glycomic alterations. Consistently, PWH

SUBMITTER: Giron LB 

PROVIDER: S-EPMC10441429 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature