Advanced-Glycation Endproducts: How cross-linking properties affect the collagen fibril behavior.

ABSTRACT: Advanced-Glycation-Endproducts (AGEs) are known to be a major cause of impaired tissue material properties. In collagen fibrils, which constitute a major building component of human tissue, these AGEs appear as fibrillar cross-links. It has been shown that when AGEs accumulate in collagen fibrils, a process often caused by diabetes and aging, the mechanical properties of the collagen fibril are altered. However, current knowledge about the mechanical properties of different types of AGEs, and their quantity in collagen fibrils is limited owing to the scarcity of available experimental data. Consequently, the precise relationship between the nano-scale cross-link properties, which differ from type to type, their density in collagen fibrils, and the mechanical properties of the collagen fibr

SUBMITTER: Kamml J 

PROVIDER: S-EPMC10441443 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature