A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.

ABSTRACT:

Background

Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (PRS_CHD) for 5 genetic ancestry groups.

Methods

We derived ancestry-specific and multi-ancestry PRS_CHD based on pruning and thresholding (PRS_P+T) and continuous shrinkage priors (PRS_CSx) applied on summary statistics from the largest multi-ancestry genome-wide meta-analysis for CHD to date, including 1.1 million participants from 5 continental populations. Following training and optimization of PRS_CHD in the Million Veteran Program, we evaluated predictive performance of the best performing PRS_CHD in 176,988 individuals across 9 cohorts of

SUBMITTER: Smith JL 

PROVIDER: S-EPMC10441485 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature