Epigenome-wide association study of incident type 2 diabetes in Black and White participants from the Atherosclerosis Risk in Communities Study.

ABSTRACT: DNA methylation studies of incident type 2 diabetes in US populations are limited, and to our knowledge none included individuals of African descent living in the US. We performed an epigenome-wide association analysis of blood-based methylation levels at CpG sites with incident type 2 diabetes using Cox regression in 2,091 Black and 1,029 White individuals from the Atherosclerosis Risk in Communities study. At an epigenome-wide significance threshold of 10^-7, we detected 7 novel diabetes-associated CpG sites in C1orf151 (cg05380846: HR= 0.89, p = 8.4 × 10^-12), ZNF2 (cg01585592: HR= 0.88, p = 1.6 × 10^-9), JPH3 (cg16696007: HR= 0.87, p = 7.8 × 10^-9), GPX6 (cg02793507: HR= 0.85, p = 2.7 × 10

SUBMITTER: Venkataraghavan S 

PROVIDER: S-EPMC10441493 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature