HUC-MSC transplantation therapy effects on lupus-prone MRL/lpr mice at early disease stages.

ABSTRACT:

Background

The efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, these trials focused on severe or refractory SLE, while few studies focused on mild SLE. Therefore, this study focused on the therapeutic effects of hUC-MSC transplantation in early-stage or mild MRL/lpr lupus model mice.

Methods

Commercially available hUC-MSCs were transplanted into 8-week-old MRL/lpr mice by tail vein injection. Flow cytometry was used to analyze B cells and their subsets in the peripheral blood. Further, plasma inflammatory factors, autoantibodies, and plasma biochemical indices were detected using protein chip technology and ELISA kits. In addition, patho

SUBMITTER: Guo F 

PROVIDER: S-EPMC10441722 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature