Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa.

ABSTRACT:

Background

Antiretroviral treatment improves health related quality of life (HRQoL) of people with human immunodeficiency virus (PWH). However, one third initiating first-line treatment experience virological failure and the determinants of HRQoL in this key population are unknown. Our study aims to identify determinants of among PWH failing antiretroviral treatment in sub-Saharan Africa.

Methods

We analysed data from a cohort of PWH having virological failure (> 1,000 copies/mL) on first-line ART in South Africa and Uganda. We measured HRQoL using the EuroQOL EQ-5D-3L and used a two-part regression model to obtain by-country analyses for South Africa and Uganda. The first part identifies risk factors that were associated with the likelihood of participants reporting perfect

SUBMITTER: Rautenberg TA 

PROVIDER: S-EPMC10441724 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature