Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8⁺ T cells to demote the antitumor immunity.

ABSTRACT:

Background

Variated anti-cancer therapies are combined with immune checkpoint blockades (ICBs) for improving ICB therapeutic efficacy. Occurrence of tissue damage is common that triggers multiple inflammatory cytokine generation. Gastrointestinal organs are the commonly affected. We investigated the impact of acute colitis on tumor infiltration of antigen-specific CD8⁺ cytotoxic T lymphocytes (CTLs) for controlling tumor growth and responding to antibody against PD-1 (anti-PD-1).

Methods

Several tumor cell lines were inoculated into syngeneic mice subcutaneously or intra-hepatically. When tumor mass formed, activated CTLs were intravenously transferred into the tumor-bearing mice, that were given the drinking water containing 2% dextran sulfate sodium (DSS) for ac

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10441727 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature