Investigation of brain iron in anorexia nervosa, a quantitative susceptibility mapping study.

ABSTRACT:

Background

Anorexia nervosa (AN) is a potentially fatal psychiatric condition, associated with structural brain changes such as gray matter volume loss. The pathophysiological mechanisms for these changes are not yet fully understood. Iron is a crucial element in the development and function of the brain. Considering the systemic alterations in iron homeostasis in AN, we hypothesized that brain iron would be altered as a possible factor associated with structural brain changes in AN.

Methods

In this study, we used quantitative susceptibility mapping (QSM) magnetic resonance imaging to investigate brain iron in current AN (c-AN) and weight-restored AN compared with healthy individuals. Whole-brain voxel wise comparison was used to probe areas with possible group differences.

SUBMITTER: Ravanfar P 

PROVIDER: S-EPMC10441741 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature