D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice.

ABSTRACT:

Background

Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play important roles in the occurrence and progression of aging. The D-galactose (D-gal)-induced aging model is well known and widely utilized in aging research. Our previous studies demonstrate that administration of D-gal causes mitochondrial oxidative damage and causes subsequent dysfunction in the cochlear ribbon synapses, which in turn leads to hearing changes and early stage presbycusis. Stria vascularis (SV) cells are vital for hearing function. However, it is unclear to what extent D-gal induces oxidative damage and apoptosis in the cochlear SV of mice. In addition, the

SUBMITTER: Peng Z 

PROVIDER: S-EPMC10441755 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature