High-fat diet in early life triggers both reversible and persistent epigenetic changes in the medaka fish (Oryzias latipes).

ABSTRACT:

Background

The nutritional status during early life can have enduring effects on an animal's metabolism, although the mechanisms underlying these long-term effects are still unclear. Epigenetic modifications are considered a prime candidate mechanism for encoding early-life nutritional memories during this critical developmental period. However, the extent to which these epigenetic changes occur and persist over time remains uncertain, in part due to challenges associated with directly stimulating the fetus with specific nutrients in viviparous mammalian systems.

Results

In this study, we used medaka as an oviparous vertebrate model to establish an early-life high-fat diet (HFD) model. Larvae were fed with HFD from the hatching stages (one week after fertilization) for six w

SUBMITTER: Inoue Y 

PROVIDER: S-EPMC10441761 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature