Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.

ABSTRACT: The impact of variants of concern (VoC) on SARS-CoV-2 viral dynamics remains poorly understood and essentially relies on observational studies subject to various sorts of biases. In contrast, experimental models of infection constitute a powerful model to perform controlled comparisons of the viral dynamics observed with VoC and better quantify how VoC escape from the immune response. Here we used molecular and infectious viral load of 78 cynomolgus macaques to characterize in detail the effects of VoC on viral dynamics. We first developed a mathematical model that recapitulate the observed dynamics, and we found that the best model describing the data assumed a rapid antigen-dependent stimulation of the immune response leading to a rapid reduction of viral infectivity. When compared with

SUBMITTER: Marc A 

PROVIDER: S-EPMC10441782 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature