Microbial Gene Ontology informed deep neural network for microbe functionality discovery in human diseases.

ABSTRACT: The human microbiome plays a crucial role in human health and is associated with a number of human diseases. Determining microbiome functional roles in human diseases remains a biological challenge due to the high dimensionality of metagenome gene features. However, existing models were limited in providing biological interpretability, where the functional role of microbes in human diseases is unexplored. Here we propose to utilize a neural network-based model incorporating Gene Ontology (GO) relationship network to discover the microbe functionality in human diseases. We use four benchmark datasets, including diabetes, liver cirrhosis, inflammatory bowel disease, and colorectal cancer, to explore the microbe functionality in the human diseases. Our model discovered and visualized the nove

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10441785 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature