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GADD45B regulates the carcinogenesis process of chronic atrophic gastritis and the metabolic pathways of gastric cancer.


ABSTRACT:

SUBMITTER: Xu W 

PROVIDER: S-EPMC10441793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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GADD45B regulates the carcinogenesis process of chronic atrophic gastritis and the metabolic pathways of gastric cancer.

Xu Wei W   Jiang Tianxiao T   Shen Kanger K   Zhao Dongxu D   Zhang Man M   Zhu Wenxin W   Liu Yunfei Y   Xu Chunfang C  

Frontiers in endocrinology 20230807


<h4>Background</h4>Gastric cancer continues to be a significant global healthcare challenge, and its burden remains substantial. The development of gastric cancer (GC) is closely linked to chronic atrophic gastritis (CAG), yet there is a scarcity of research exploring the underlying mechanisms of CAG-induced carcinogenesis.<h4>Methods</h4>In this study, we conducted a comprehensive investigation into the oncogenes involved in CAG using both bulk transcriptome and single-cell transcriptome data.  ...[more]

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