Direct and indirect effects of age on dengue severity: The mediating role of secondary infection.

ABSTRACT: Severe dengue occurrence has been attributed to increasing age and different dengue virus (DENV) serotypes that cause secondary infections and immune-enhancing phenomena. Therefore, we examined if the effect of age on dengue severity was mediated by infectivity status while controlling for sex and region. Further, we assessed the spatial clustering of dengue severity for individuals with primary and secondary infection across Mexican municipalities. Health data from 2012 to 2017 was retrieved from Mexico's Ministry of Health. A mediation analysis was performed using multiple logistic regression models based on a directed acyclic graph. The models were explored for the direct effect of age on dengue severity and its indirect impact through secondary infection. In addition, severe dengue clu

SUBMITTER: Annan E 

PROVIDER: S-EPMC10441797 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature