Investigating the ability of astrocytes to drive neural network synchrony.

ABSTRACT: Recent experimental works have implicated astrocytes as a significant cell type underlying several neuronal processes in the mammalian brain, from encoding sensory information to neurological disorders. Despite this progress, it is still unclear how astrocytes are communicating with and driving their neuronal neighbors. While previous computational modeling works have helped propose mechanisms responsible for driving these interactions, they have primarily focused on interactions at the synaptic level, with microscale models of calcium dynamics and neurotransmitter diffusion. Since it is computationally infeasible to include the intricate microscale details in a network-scale model, little computational work has been done to understand how astrocytes may be influencing spiking patterns and

SUBMITTER: Handy G 

PROVIDER: S-EPMC10441806 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature