A Fur-regulated type VI secretion system contributes to oxidative stress resistance and virulence in Yersinia pseudotuberculosis.

ABSTRACT: The type VI secretion system (T6SS) is a widespread protein secretion apparatus deployed by many Gram-negative bacterial species to interact with competitor bacteria, host organisms, and the environment. Yersinia pseudotuberculosis T6SS4 was recently reported to be involved in manganese acquisition; however, the underlying regulatory mechanism still remains unclear. In this study, we discovered that T6SS4 is regulated by ferric uptake regulator (Fur) in response to manganese ions (Mn²⁺), and this negative regulation of Fur was proceeded by specifically recognizing the promoter region of T6SS4 in Y. pseudotuberculosis. Furthermore, T6SS4 is induced by low Mn²⁺ and oxidative stress conditions via Fur, acting as a Mn²⁺-responsive transcriptional regulator to m

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC10441874 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature