A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov.

ABSTRACT: Combination therapies have taken center stage for cancer treatment, however, there is a lack of a comprehensive portrait to quantitatively map the current clinical combination progress. This study aims to capture clinical combination therapies of the validated FDA-approved new oncology drugs by a macro data analysis and to summarize combination mechanisms and strategies in the context of the existing literature. A total of 72 new molecular entities or new therapeutic biological products for cancer treatment approved by the FDA from 2017 to 2021 were identified, and the data on their related 3334 trials were retrieved from the database of ClinicalTrials.gov. Moreover, these sampled clinical trials were refined by activity status and combination relevance and labeled with the relevant clinic

SUBMITTER: Yang J 

PROVIDER: S-EPMC10441974 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature