Optimal examined lymph node number for accurate staging and long-term survival in rectal cancer: a population-based study.

ABSTRACT:

Background

Although the recommended minimal examined lymph node (ELN) number in rectal cancer (RC) is 12, this standard remains controversial because of insufficient evidence. We aimed to refine this definition by quantifying the relationship between ELN number, stage migration and long-term survival in RC.

Methods

Data from a Chinese multi-institutional registry (2009-2018) and the Surveillance, Epidemiology, and End Results (SEER) database (2008-2017) on stages I-III resected RC were analysed to determine the relationship between ELN count, stage migration, and overall survival (OS) using multivariable models. The series of odds ratios (ORs) for negative-to-positive node stage migration and hazard ratios (HRs) for survival with more ELNs were fitted using a Locally Weighte

SUBMITTER: Guan X 

PROVIDER: S-EPMC10442141 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature