Combining molecular dynamics simulations and scoring method to computationally model ubiquitylated linker histones in chromatosomes.

ABSTRACT: The chromatin in eukaryotic cells plays a fundamental role in all processes during a cell's life cycle. This nucleoprotein is normally tightly packed but needs to be unpacked for expression and division. The linker histones are critical for such packaging processes and while most experimental and simulation works recognize their crucial importance, the focus is nearly always set on the nucleosome as the basic chromatin building block. Linker histones can undergo several modifications, but only few studies on their ubiquitylation have been conducted. Mono-ubiquitylated linker histones (HUb), while poorly understood, are expected to influence DNA compaction. The size of ubiquitin and the globular domain of the linker histone are comparable and one would expect an increased disorder upon ubiq

SUBMITTER: Sawade K 

PROVIDER: S-EPMC10442151 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature