The QT_c-Bazett Interval in Former Very Preterm Infants in Adolescence and Young Adulthood is Not Different from Term-Born Controls.

ABSTRACT:

Introduction

Although relevant for precision pharmacovigilance, there are conflicting data on whether former preterm birth is associated with QT_c-Bazett prolongation in later life.

Methods

To explore QT_c-Bazett interval differences between former preterm and/or extremely low birth weight (ELBW) cases and term-born controls in adolescence and young adulthood, we analyzed pooled individual data after a structured search on published cohorts. To test the absence of a QT_c-Bazett difference, a non-inferiority approach was applied (one-sided, upper limit of the 95% confidence interval [CI] mean QT_c-Bazett difference, 5 and 10 ms). We also investigated the impact of characteristics, either perinatal or at assessment, on QT_c-Bazett

SUBMITTER: Vanthienen J 

PROVIDER: S-EPMC10442256 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature