Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study.

ABSTRACT: Affective disorders are associated with accelerated cognitive ageing. However, current understanding of biological mechanisms which underlie these observed associations is limited. The aim of this study was to test: 1) Whether cortisol acts as a pathway in the association between depressive or anxiety symptoms across adulthood and midlife cognitive function; 2) Whether cortisol is associated with later depressive or anxiety symptoms, and cognitive function. Data were used from the National Child Development Study (NCDS), a sample of infants born in mainland UK during one week of 1958. A measure of the accumulation of affective symptoms was derived from data collected from age 23 to 42 using the Malaise Inventory Scale. Salivary cortisol measures were available at age 44-45. Cognitive funct

SUBMITTER: John A 

PROVIDER: S-EPMC10442295 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature